张宗德 男，医学博士，教授/研究员，博士研究生导师。现任首都医科大学附属北京胸科医院副院长，北京市结核病胸部肿瘤研究所副所长，耐药结核病研究北京市重点实验室主任。

  研究方向包括结核病快速诊断分子标识物筛选和临床应用研究、结核病发生发展的分子机制研究、以及抗结核药物耐药机制研究。主持国家自然科学基金、国家科技重大专项等国家级、省部级课题 20 余项。近 5 年在国内外期刊发表科研文章 50 余篇，其中 SCI 文章 20 余篇，累计影响因子 80 余分；授权国家发明专利 2 项；参与编写《Molecular Biology of Tuberculosis》、《非结核分枝杆菌病诊断与治疗》《现代结核病学》、《耐药结核病》、《现代结核病控制—理论与实践》等多部专著。先后获得中国防痨协会首届优秀科技工作者奖、北京市科技进步二等奖（2 次）、北京市科技新星、北京市卫生系统高层次卫生技术人才、北京市医院管理局登峰人才、北京市“通州区高层次人才发展支持计划”领军和顶尖人才、通州科技创新人才奖等荣誉称号。兼任中国防痨协会副理事长，中国医促会结核病分会副主任委员、北京医学会结核病分会常委，中华医学会结核病学分会委员；兼任 BMC Infectious Dieases杂志副主编、中华结核和呼吸杂志编委、Tuberculosis、International Tuberculosisand Lung Diseases、中华医学杂志英文版、中华医学杂志、中华结核和呼吸杂志、中华检验医学杂志等医学期刊审稿人。近 5 年培养博士、硕士研究生 10 余名。

代表作：

1. Zihui Li#, Liping Pan#, Lingna Lv#, Jing Li, Hongyan Jia, Boping Du, ZongdeZhang*. Diagnostic accuracy of droplet digital PCR analysis of cerebrospinal fluid fortuberculous meningitis in adult patients. Clin Microbiol Infect. 2020Feb;26(2):213-219. 

2. Chuanzhi Zhu#, Yi Cai#, Jialou Zhu, Lanyue Zhang, Aiying Xing, Liping Pan, Hongyan Jia, Siwei Mo, carl Feng, Hongbo Shen, Xinchun Chen*, Zongde Zhang*. Histone deacetylase inhibitors impair the host immune response againstMycobacterium tuberculosis infection. Tuberculosis, 2019 Sep;118: 101861. 

3. Liping Pan#, Fei Liu#, Jinli Zhang, Jing Li, Hongyan Jia, Mailing Huang, XuehuaLiu, Weibi Chen, Zeyu Ding, Yajie Wang, Boping Du, Rongrong Wei, Qi Sun, AiyingXing, Zongde Zhang*. Genome-wide miRNA analysis identifies potential biomarkersin distinguishing tuberculous and viral meningitis. Front Cell Infect Microbiol. 2019, 9: 323. 

4. Tingming Cao#, Lingna Lyu#, Hongyan Jia, Jinghui Wang, Fengjiao Du, LipingPan, Zihui Li, Aiying Xing, Jing Xiao, Yu Ma, Zongde Zhang*. A Two-Way ProteomeMicroarray Strategy to Identify Novel Mycobacterium tuberculosis-HumanInteractors. Front Cell Infect Microbiol. 2019, Mar 28; 9:65. 

5. Jing Xiao, Hongyan Jia, Liping Pan, Zihui Li, Lingna Lv, Boping Du, LanyueZhang, Fengjiao Du, Yinxia Huang, Tingming Cao, Qi Sun, Rongrong Wei, AiyingXing, Zongde Zhang*. Application of the CRISPRi system to repress sepF expressionin Mycobacterium smegmatis. Infection, Genetics and Evolution. 2019, July 6, 72:183-190.

林舒晔 女，北京大学医学博士，首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所副研究员，硕士研究生导师。

  主要研究方向聚焦于表观遗传调控基因可变剪接导致的肿瘤异质性研究，开展识别肿瘤早期及耐药诊断标物和鉴定肿瘤个体化诊疗靶标。以项目负责人主持各级课题 7 项，包括国家自然科学基金、北京市教委科技计划等项目。发表研究论文 16 篇，其中 11 篇为第一作者或通讯作者，包括 Clinical Cancer Research、Acta Pharma Sin B、Int J Biol Sci、Gastric Cancer 及 Antioxidants & Redox Signaling 等期刊。入选北京市医管中心“青苗”计划人才项目，授权国家发明专利 4 项。担任 Traditional Medicine Research、Acta Materia Medica 杂志青年编委。

代表作：（# 第一作者，* 通讯作者）

1.Shuye Lin, Hanli Xu, Lin Qin, Mengdi Pang, Ziyu Wang, Meng Gu, Lishu Zhang, Cong Zhao, Xuefeng Hao, Zhiyun Zhang, Weimin Ding, Jianke Ren, Jiaqiang Huang*. UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer. Acta Pharma Sin B, 2023, doi:10.1016/j.apsb.2023.02.015 

2.Shuye Lin#, Xiaoyue Wang#, Yuanming Pan#, Mengrong Tian, Bonan Lin, Guosheng Jiang, Keqiang Chen, Yuqi He, Lulu Zhang, Wanli Zhai, Peng Jin, Lang Yang, Guoqiang Li, Yun Wu, Jiang Hu, Wanghua Gong, Zhijie Chang, Jianqiu Sheng, Youyong Lu, Ji Ming Wang, Jiaqiang Huang*. Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A. Clinical Cancer Research, 2019, 25(3):1050-1062. 

3.Shuye Lin#*, Hongyun Ruan#, Lin Qin #, Cong Zhao, Meng Gu, Ziyu Wang, Bin Liu*, Haichao Wang*, Jinghui Wang*. Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex. International Journal of Biological Sciences, 2023, 19(3): 832-851. 

4.Shuye Lin, Yaping Zhang, Yingqi Hu, Bing Yang, Jiantao Cui, Jiaqiang Huang, Ji Ming Wang, Rui Xing*, Youyong Lu*. Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer, 2019, 22(5):941-954. 

5.Shuye Lin#, Hanli Xu#, Mengdi Pang, Xiaomeng Zhou, Yuanming Pan, Lishu Zhang, Xin Guan, Xiaoyue Wang, Bonan Lin, Rongmeng Tian, Keqiang Chen, Xiaochen Zhang, Zijiang Yang, Fengmin Ji, Yingying Huang, Wu Wei, Wanghua Gong, Jianke Ren, Ji Ming Wang, Mingzhou Guo*, Jiaqiang Huang*. CpG Site-Specific Methylation-modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma. Frontiers in Oncology, 2022; 11;12:831268.

杜建 男，医学博士，研究员，硕士生导师。现任首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所办公室主任，兼管转化办公室。

  研究方向包括结核病流行病学、免疫学及结核病感染控制，结核病防治策略及患者信息化管理等。承担国家“十二五”、“十三五”传染病科技重大专项任务 “结核病综合管理模式的研究”及“复治肺结核病化学治疗新方案的中期疗效与安全性研究”。发表 SCI 论文 20 余篇，国内核心期刊 20 余篇。担任中华医学会结核病学分会副主任委员、秘书长，北京结核病诊疗技术创新联盟秘书长。北京市卫健委“高层次公共卫生人才项目”学科带头人，中华医学会国际交流与合作及港澳台事务专家委员会委员。

  代表作：

1.Jian Du J ; Qing Li; Min Liu; Yufeng Wang; Zhongtan Xue; Fengmin Huo; Xuxia Zhang;Yuanyuan Shang; Shanshan Li; Hairong Huang; Yu Pang ; Distinguishing Relapse From ReinfectionWith Whole- Genome Sequencing in Recurrent Pulmonary Tuberculosis: A Retrospective CohortStudy in Beijing, China, Frontiers in Microbiology（DOI：10.3389/fmicb.2021.754352）, 2021, 12 . 

2.Jian Du J ; Jingtao Gao; Yanhong Yu; Qingfeng Li; Guanghong Bai; Wei Shu; Mengqiu Gao;Yuhong Liu; Lu Wang; Yufeng Wang; Zhongtan Xue; Fengmin Huo; Liang Li; Yu Pang ; Low Rate ofAcquired Linezolid Resistance in Multidrug-Resistant Tuberculosis Treated With Bedaquiline- Linezolid Combination, Frontiers in Microbiology（DOI：10.3389/fmicb.2021.655653）, 2021, 12. 

3.Jian Du J ; Wei Shu; Yuhong Liu; Yufeng Wang; Ying Zhan; Kexin Yu; Jingtao Gao; Liang Li; YuPang ; Multicenter feasibility study to assess external quality panels for molecular diagnostics fortuberculosis in China, European Journal of Clinical Microbiology & Infectious Diseases, 2020, 39:339-343. 

4.Jian Du J ; Le Zhang; Yan Ma; Xiao-you Chen; Qiping Ge; X.-Z. Tian; Weiwei Gao; Zhongwei Jia ;Treatment and recurrence on re-treatment tuberculosis patients: a randomized clinical trial and7-year perspective cohort study in China, European Journal of Clinical Microbiology & InfectiousDiseases（DOI：10.1007/s10096-019-03696-8）, 2019 . 

5.Jian Du J ; Lijie Zhang; Yuhong Liu; Wei Shu; Yan Ma; Jingtao Gao; Liang Li ; Determination ofthe optimal time for N95 respirator for aerosol infection control, Medicine （ DOI ：10.1097/md.0000000000023709）, 2020, 99(50): e23709 .

李姗姗 女，医学博士，副研究员，硕士研究生导师一直致力于结核病免疫学诊断技术研发和抗结核天然免疫应答机制研究，先后主持 1 项国家自然科学基金青年基金，1 项首都临床特色诊疗技术研究及转化应用项目，2 项局级课题（首都医科大学 2022 年培育基金、市教委 2022 年科技计划一般项目）和 2 项院级课题，相关研究成果以通讯作者或第一作者（含共同通讯或共同第一作者）在 Emerg Microbes Infect、Frontiers in Microbiology、Journal of Molecular Diagnostics 等 SCI 杂志发表论文 20篇，发表中文核心期刊论文 3 篇，总影响因子 129.385 分。社会兼职：中华医学会结核病学分会第十八届委员会结核病临床检验专业委员会委员

  代表作（#第一作者，*通讯作者）：

1.Yunfeng Deng#, Zichun Ma#, Biyi Su#, Guanghong Bai#, Jianhua Pan#, Quan Wang#, Long Cai#, Yanhua Song#, Yuanyuan Shang, Pinyun Ma, Jing Li, Qianxuan Zhou, Gulibike Mulati, Dapeng Fan, Shanshan Li*, Yaoju Tan*, Yu Pang*. Accuracy of the InnowaveDX MTB/RIF test for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre study. Emerg Microbes Infect. 2023 Dec;12(1):2151382.

2.Xiao Wu#, Yuanyuan Shang#, Weicong Ren, Wei Wang, Yufeng Wang, Zhongtan Xue, Shanshan Li*, Yu Pang*. Minimum inhibitory concentration of cycloserine against Mycobacterium tuberculosis using the MGIT 960 system and a proposed critical concentration. Int J Infect Dis. 2022 May 13;121:148-151.

3.Haoran Li#, Gulibike Mulati#, Yuanyuan Shang#, Cong Yao, Yufeng Wang, Weicong Ren, Zhongtan Xue, Shanshan Li*, Yu Pang*. Rapid Detection of Clarithromycin and Amikacin Resistance in Mycobacterium abscessus Complex by High-Resolution Melting Curve Analysis. Microbiol Spectr. 2022 May 31:e0057422.

4.Min Qiao#, Shanshan Li#, Jinfeng Yuan#, Weicong Ren#, Yuanyuan Shang, Wei Wang, Rongmei Liu, Fuzhen Zhang, Qing Li, Xiao Wu, Jie Lu*, Mengqiu Gao*, Yu Pang*. Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients. Front Immunol. 2022 Nov 8;13:923492.

5.Shanshan Li #, Jidong Guo #, Rongmei Liu #, Fuzhen Zhang, Shu'an Wen, Yi Liu, Weicong Ren, Xuxia Zhang, Yuanyuan Shang, Mengqiu Gao*, Jie Lu*, Yu Pang*. Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis. Microbiol Spectr. 2022 Dec 21;10(6):e0192622.

刘文静 女，中国科学院大学博士，北京理工大学/国家纳米科学中心博后，现任首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所副研究员，硕士生导师，任中国生物物理学会纳米生物学分会会员和中国抗癌协会纳米肿瘤学分会会员。研究兴趣集中在利用DNA纳米技术工程化生物材料和纳米材料，并基于这些工程化材料设计新型诊断治疗剂，用于疾病的诊断和治疗。主持国自然基金一项，近五年以第一作者发表在ACS AppliedMaterials and Interfaces, Analytical Chemistry,Nanoscale等6篇SCI;获得发明专利一项。

代表作：

1.Wenjing Liu, Yunayu Huang*."Cell membrane-engineered nanoparticles for cancer therapy".Journal of Materials Chemistry B.2022.

2.Wenjing Liu,Yuanyu Huang, Zhenping Li, Lele Li,Yuliang Zhao, Mengyuan Li*,"Multivalentengineering of exosomes with activatable aptamer probes for specific regulation and monitoring ofcell targeting." Analytical Chemistry.2022,94(9), 3840-3848.

3.Wenjing liu, Yourong Guo, Kaizhe Wang,Xingfei Zhou, Ying Wang, Junhong Lv, Zhifeng Shao,Jun Hu*,Daniel M. Czajkowsky*,Bin Li*."Atomic force microscopy-based single-molecule forcespectroscopy detects DNA base mismatches" Nanoscale.2019,11(37):17206-17210.

4. Wenjing Liu,Zetan Fan, Lele Li*,Mengyuan Li*,"DNA-Based Nanoprobes for SimultaneousDetection of Telomerase and Correlated Biomolecules" Chembiochem. 2022, 23(21):e202200307.doi:10.1002/cbic.202200307.

5. Wenjing Liu; Ping Zhang; Tong Sun; Lin Li; Yuhui Wei; Kaizhe Wang; Lin Liu; Bin Li; Effectof concentration and adsorption time on the formation of a large-scale origami pattern,NuclearScience & Techniques, 2019,30(7):111-111.

6.Ping Zhang#,Feng Wang#,Wenjing Liu#,Xiuhai Mao, Changchun Hao,Yi Zhang* ChunhaiFan,Jun Hu,Lihua Wang*, Bin Li*."Quantitative Measurement of Spatial Effects of DNAOrigami on Molecular Binding Reactions Detected using Atomic Force Microscopy." ACS Appl.Mater.Interfaces.2019,11(24):21973-21981.(#co-first author).

刘毅 男，博士，研究员，硕士研究生导师，现任首都医科大学附属北京胸科医院生物样本与数据资源库主任助理。在基础医学和生物学等相关领域从事研究工作已 10 多年，主要方向为微生物免疫学、诊断新技术和分子流行病学研究。入选北京市医院管理中心青苗人才、北京市通州区运河计划领军人才、北京市优秀人才等项目；主持和参加北京市教委科技计划、首都卫生发展科研专项、国家自然科学基金和国家科技重大专项等多项课题的研究工作。曾获武田奖学金支持在东京大学医科学研究所从事博士后和客员研究员工作，并在国家卫健委科教司挂职从事传染病重大专项实施管理工作。发表 SCI 和核心期刊论文 20 多篇，参编专著 4 部。现任中国防痨协会基础委员会委员；中华医学会结核病学分会基础委员会委员；中国研究型医院学会空间微生物与感染疾病分会青年委员；北京防痨协会基础专业委员会常委。

代表作：

1.Liu Y*, Sun Y, Zhang X, Zhang Z, Xing Q, Ren W, Yao C, Yu J, Ding B, Wang S, Li C*. Evaluation of the frequency of mutation genes in multidrug-resistant tuberculosis (MDR-TB) strains in Beijing, China. Epidemiol Infect. 2021 Jan 5;149:e21. doi: 10.1017/S0950268820003131. PMID: 33397543; PMCID: PMC8057498.

2.Liu Y*, Zhang XX, Yu JJ, Liang C, Xing Q, Yao C, Li CY*. Tuberculosis relapse is more common than reinfection in Beijing, China. Infect Dis (Lond). 2020 NovDec;52(12):858-865. doi: 10.1080/23744235.2020.1794027. Epub 2020 Jul 16. PMID: 32673126.

3.Liu Y, Zhang X, Zhang Y, Sun Y, Yao C, Wang W, Li C. Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission. BMC Infect Dis. 2018 Dec 14;18(1):658. doi: 10.1186/s12879-018-3578-7. PMID: 30547765; PMCID: PMC6295058.

4.Liu Y*, Jiang X, Li W, Zhang X, Wang W, Li C*. The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing. Sci Rep. 2017 Nov 8;7(1):15076. doi: 10.1038/s41598-017-14119-z. PMID: 29118425; PMCID: PMC5678160.

5.Liang C, Li X, Li Q, Zhang X, Ren W, Yao C, Pang Y, Liu Y*, Li C*, Tang S*. Clinical isolates of Mycobacterium tuberculosis with different genotypes exhibit distinct host macrophage responses in vitro. J Med Microbiol. 2022 Dec;71(11). doi: 10.1099/jmm.0.001604. PMID: 36748527.